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姓名:杨恺

职称:教授

直属机构:9728见好就收才是赢

学位:博士

学历:博士

毕业院校:南京大学

毕业专业:软物质物理/生物物理

通讯地址:

邮编:

电子邮箱:yangkai@suda.edu.cn

联系电话:0512-65220239

传真:

办公地址:物理科技楼234房间


个人简介

个人简介:

教育经历

2006-2009,南京大学物理学系,获理学博士学位(专业:软物质物理)

2000-2003,云南大学材料科学与工程系,获硕士学位(专业:凝聚态物理)

1996-2000,云南大学物理系数理基地班,获学士学位(专业:物理学)

EDUCATION

2006-2009, Ph.D. in Physics, Nanjing University
2000-2003, M.S. in Condensed Physics, Yunnan University
1996-2000, B. S. in Physics, Yunnan University


工作经历

2015-至 今,苏州大学9728见好就收才是赢/软凝聚态物理及交叉研究中心,特聘教授,博士生导师

2014-2015,美国康奈尔大学分子生物和基因遗传学系,访问学者/副教授

2010-2015,苏州大学物理与光电·能源学部/软凝聚态物理及交叉研究中心,特聘副教授,硕士生导师

2003-2010,云南民族大学物理与电子电气信息工程学院,讲师/副教授

PROFESSIONAL EXPERIENCE:

2015-       ,Professor at Soochow University

2014-2015, Visiting Associate Professor at Cornell University

2010-2015, Associate Professor at Soochow University

2003-2010, Assistant Professor at Yunnan Minzu University

荣誉奖励

  1. 江苏省科学技术二等奖,纳米材料与细胞界面作用的构建、机理及调控(3/4),2019年

  2. 江苏省第五期“333高层次人才培养工程”培养对象(第三层次,2016年)

  3. 国家自然科学基金优秀青年科学基金项目获得者(2014年)

  4. 全国优秀博士学位论文提名奖(2012年)

  5. 南京微结构固体物理国家重点实验室研究生优秀成果奖

  6. 苏州市高等院校、科研院所紧缺高层次人才



GROUP NEWS



祝贺卢雪梅同学通过博士论文答辩,并获得苏州文正学院教职!



* 祝贺马文东同学通过硕士答辩! 


* 祝贺邓智雄同学获得2020年江苏省研究生培养创新工程研究生科研与实践创新计划!Congrats!


祝贺尤鑫同学(课题组本科生)获得“2020年省级大学生创新创业训练计划项目”支持!Congrats!


* 卢雪梅、刘娇娇关于石墨烯-melittin复合结构论文被MaterialsViewsChina报道!

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* 祝贺卢雪梅同学获得中国化学会2018年软物质理论计算与模拟学术会议优秀墙报奖!Congrats!
祝贺卢雪梅同学获得
2018
年江苏省研究生培养创新工程研究生科研与实践创新计划
!Congrats!
祝贺林召、吴晋锋和徐玉亭同学(课题组本科生)获得“2018年省级大学生创新创业训练计划项目(省级重点项目)”支持!Congrats

祝贺葛宇柯(课题组本科生)获得苏州大学
第二十批大学生课外学术科研基金重点项目!Congrats
祝贺常琪同学(课题组本科生)在江苏省高校第十四届大学生物理及实验科技作品创新竞赛中荣获一等奖!Congrats

祝贺葛宇柯和朱伊尼同学(课题组本科生)获得“2017年苏州大学校级大学生创新创业训练计划项目”支持!Congrats

* 祝贺常琪同学(课题组本科生)大学生创新计划研究成果在SCI收录杂志Chin. Phys. B发表!Congrats
* 祝贺刘娇娇同学通过博士论文答辩!卢雪梅同学和王瑞同学通过硕士论文答辩!Congrats
* 祝贺!卢雪梅同学APL文章 (Appl. Phys. Lett. 110, 023701, 2017) 被选为杂志封面和APL Editor's Picks


研究领域

研究领域:

围绕“细胞生物物理机制+纳米生物技术+生物医药应用”等主题开展研究

研究方向

1.  细胞相关的生命现象及物理机制;细胞膜的相行为,细胞界面-蛋白质/多肽相互作用;

2.  Nano-Bio相互作用,纳米药物(抗肿瘤、抗菌机理研究),生物材料;

3.  生命软物质体系的自组织/组装;
4.  生物/高分子体系的分子模拟(计算)及其与实验结合。

研究特色

机制 + 应用
模拟理论 + 实验
物理 + 化学 + 生物 + 纳米


科研项目

科研项目:
科学研究(旧版):

主要从事细胞生物物理等方面的研究。目前已在Nature Nanotechnology、Biomaterials、Small等国际知名杂志发表学术论文三十余篇,特别是在纳米粒子与细胞相互作用机制和生物膜的形变现象方面取得过多项成果,其中,关于几何纳米粒子入侵细胞膜方面的研究结果被Nature China和科学时报作为Research Highlights进行评述;关于几何纳米粒子内吞机制的部分研究结果入选Biomaterials Images 2012poster;有关生物膜形变、分裂机制方面的评述文章入选了《Soft Matter》杂志2011年11月“Top Ten most-read SoftMatter articles”;Janus纳米粒子在细胞膜微尺度运动的调控和自发旋转行为的研究结果被Small杂志选作封面文章(Cover Paper),同时还被MaterialsViewsChina网站作为研究新闻进行了报道。

项目与课题(在研和完成

1. 中国国家自然科学基金优秀青年科学基金项目:细胞膜生物物理和生物大分子, 主持
2. 中国国家自然科学基金面上项目:利用碳基纳米材料增强多肽抗菌性能的分子机制研究, 主持

3. 中国国家自然科学基金面上项目:细胞内吞路径中与膜重构现象相关的协作机制研究, 主持

4. 中国国家自然科学基金青年项目:几何纳米粒子与生物膜相互作用机制及其有序化研究, 主持
5中国国家自然科学基金海外及港澳学者合作研究基金:单纳米颗粒旋转追踪技术在细胞膜相关过程中的应用, 国内合作者(Prof. N. Fang, Georgia State University)

6. 教育部科学技术研究重点项目:基于生物膜和纳米粒子相互作用的生物传感器机理研究, 主持
7江苏省自然科学基金面上项目:抗菌肽生物活性调控机制研究, 主持

8. 江苏省自然科学基金面上项目:细胞内吞路径中生物膜形变机制的计算机模拟研究, 主持

9. 苏州大学人才引进启动经费


科技成果

软件著作 软件著作: 专利 专利:

论文

论文成果:

47. Wendong Ma#, Shuqing Sun#, Wenwen Li#, Zhihong Zhang, Zhao Lin, Yu Xia, Bing Yuan*, and Kai Yang*, Individual Roles of Peptides PGLa and Magainin 2 in Synergistic Membrane Poration. Langmuir 2020, dx.doi.org/10.1021/acs.langmuir.0c00194.

 

46. Cheng Xu#, Wendong Ma#, Kang Wang, Kejie He, Zhonglan Chen, Jiaojiao Liu, Kai Yang*, and Bing Yuan*, Correlation between Single-Molecule Dynamics and Biological Functions of Antimicrobial Peptide Melittin. J. Phys. Chem. Lett. 2020, 11, 4834−4841.

 

45. Cheng Xu, Zhao Lin, Kai Yang*, Bing Yuan*, Single molecular kinetics during the interactions between melittin and a bi-component lipid membrane. Acta Physica Sinica (物理学报) 2020, 69, 108701.

 

44. Zhixiong Deng, Xuemei Lu, Cheng Xu, Bing Yuan* and Kai Yang*, Lipid-Specific Interactions Determine the Organization and Dynamics of Membrane-Active Peptide Melittin. Soft Matter 2020, 16, 3498–3504. (Invited paper)

 

43. Bin Dong, Yuchen Pei, Nourhan Mansour, Xuemei Lu, Kai Yang, Wenyu Huang*, and Ning Fang*, Deciphering Nanoconfinement Effects on Molecular Orientation and Reaction Intermediate by Single Molecule Imaging. Nat. Commun. 2019,10: 4815.

 

42. Zhixiong Deng, Jingliang Li, Bing Yuan* and Kai Yang*, Residue-Specialized Membrane Poration Kinetics of Melittin and Its Variants: Insight from Mechanistic Landscapes. Commun. Theor. Phys. 2019, 71: 887–902 (Editor’s Suggestion).


41. Jiajia Hong, Xuemei Lu, Zhixiong Deng, Shufeng Xiao, Bing Yuan* and Kai Yang*, How Melittin Inserts into Cell Membrane: Conformational Changes, Inter-Peptide Cooperation, and Disturbance on the Membrane. Molecules, 2019, 24, 1775 (Invited Review).


40. Shufeng Xiao#, Xuemei Lu#, Lu Gou#, Jingliang Li, Yuqiang Ma, Jiaojiao Liu*, Kai Yang*, Bing Yuan*, Graphene oxide as antibacterial sensitizer: Mechanically disturbed cell membrane for enhanced poration efficiency of melittin. Carbon, 2019, 149, 248-256.


39. Xuemei Lu#, Jiaojiao Liu#, Lu Gou#, Jingliang Li, Bing Yuan*, Kai Yang*, and YuqiangMa*,  Designing Melittin-Graphene HybridComplexes for Enhanced Antibacterial Activity. Adv. Healthcare Mater., 2019,1801521.


38. Kai Yang#, Ran Yang#, Xiaodong Tian#, Kejie He, Seth Leon Fibrun, Ning Fang, Yuqiang Ma and Bing Yuan*, Partitioning of nanoscale particles on a heterogeneous multicomponent lipid bilayer. Phys. Chem. Chem. Phys., 2018, 20, 28241-28248.

37. Jiaojiao Liu, Shufeng Xiao, Jingliang Li, Bing Yuan*, Kai Yang*, Yuqiang Ma, Molecular details on the intermediate states of melittin action on a cell membrane. BBA-Biomembranes, 2018, 1860, 2234-2241.

36.
 Jiaojiao Liu, Bin Song, Jingliang Li, Xiaodong Tian, Yuqiang Ma, Kai Yang* and Bing Yuan*, Photoluminescence modulation of silicon nanoparticles via highly ordered arrangement with phospholipid membranes, Colloids and Surfaces B: Biointerfaces
, 2018, 170, 656-662.

35.
 Wenbin Wang, Ran Yang, Fei Zhang, Bing Yuan*, Kai Yang* and Yu-qiang Ma, Partner-facilitating transmembrane penetration ofnanoparticles: a biological test in Silico, Nanoscale, 2018, 10, 11670-11678.

34. 
Ming Wen, Mengjie Liu, Wentao Xue, Kai Yang, Gaojian Chen*, and Weidong Zhang*Simple and Green Strategy for the Synthesis of “Pathogen-Mimetic” Glycoadjuvant@AuNPs by Combination of Photoinduced RAFT and Bioinspired Dopamine ChemistryACS Macro Lett., 2018, 7, 70-74

33. Jiao-Jiao Liu#, Qi Chang#, Mei-Mei Bao, Bing Yuan*, Kai Yang*, and Yu-Qiang Ma, Silicon quantum dots delivered phthalocyanine for fluorescence guided photodynamic therapy of tumor, Chin. Phys. B, 2017, 26, 098102. (#equal contribution)

32. Fei Zhao, Kuancai Chen, Bin Dong, Kai Yang*, Yan Gu*, and Ning Fang*, Localization accuracy of gold nanoparticles in single particle orientation and rotational tracking, Optics Express, 2017, 25, 9860-9871.

 

31. Jiaojiao Liu, Rui Wang, Sicong Wu, Bing Yuan*, Meimei Bao, Jingliang Li, Yujiang Dou, Yao He and Kai Yang*, One-pot synthesis of silicon based nanoparticles with incorporated phthalocyanine for long-term bioimaging and photo-dynamic therapy of tumors. Nanotechnology, 2017, 28, 135601.



30. Ye Li, Bing Yuan, Kai Yang*, Xianren Zhang, Bing Yan and Dapeng Cao*. Counterintuitive cooperative endocytosis of like-charged nanoparticles in cellular internalization: computer simulation and experiment. Nanotechnology, 2017, 28, 085102.

29. Xue-mei Lu, Bing Yuan*, Xian-ren Zhang, Kai Yang*, and Yu-qiang Ma. Molecular modeling of transmembrane delivery of paclitaxel by shock waves with nanobubbles. Applied Physics Letters, 2017, 110, 023701. (Cover paper, APL Editor's Pick)

28. Bing Yuan*, Xiangxu Jiang, Chu Yao, Meimei Bao, Jiaojiao Liu, Yujiang Dou, Yinze Xu,Yao He*, Kai Yang*, Yuqiang Ma. Plasmon-enhanced fluorescence imaging with silicon-based silver chips for protein and nucleic acid assay. Analytica Chimica Acta, 2017, 955, 98-107 (Featured Article).

27. Jiaojiao Liu, Xiaodong Tian, Meimei Bao, Jingliang Li, Yujiang Dou, Bing Yuan*, Kai Yang* and Yuqiang Ma. Manipulation of cellular orientation and migration byinternalized magnetic particles. Materials Chemistry Frontiers, 2017, 1, 933-936 (Invited Paper).

26.Jiaojiao Liu, Bing Yuan*, Xuewu Wu, Jingliang Li, Fangming Han, Yujiang Dou, Muzi Chen,Zhaohui Yang*, Kai Yang*, Yuqiang Ma. Modulated enhancement in ion transport through carbon nanotubes by lipid decoration. Carbon, 2017, 111, 459-466.

25. Qiu-Ju Ji, Bing Yuan, XueMei Lu, Kai Yang*, and Yu-Qiang Ma*. Controlling the Nanoscale Rotational Behaviors of Nanoparticles on the Cell Membranes: A Computational Model. Small, 2016, 12, 1140-1146 (Cover paper, Highlighted byMaterialsViewsChina http://www.materialsviewschina.com/2015/11/18012/).

24. Jiaojiao Liu, Meimei Bao, Jingliang Li, Yuyan Weng, Yujiang Dou, Bing Yuan*, Kai Yang,Yuqiang Ma*. Modulated deformation of lipid membrane to vesicles and tubes dueto reduction of graphene oxide substrate under laser irradiation. Carbon, 2016,98, 300-306.

23. FanXu, Meimei Bao, Longfei Rui, Jiaojiao Liu, Jingliang Li, Yujiang Dou, Kai Yang, Bing Yuan* and Yuqiang Ma*. Self-assembly of monolayered lipid membranes for surface-coating of a nanoconfined Bombyx mori silk fibroin film. RSC Adv.,2015, 5, 65684-65689.

22. Haizhen Zhang, Qiuju Ji, Changjin Huang, Sulin Zhang, Bing Yuan, Kai Yang*, and Yuqiang Ma. Cooperative Transmembrane Penetration of Nanoparticles. Scientific Reports, 2015, 5, 10525.

21. Longfei Rui, Jiaojiao Liu, Jingliang Li, Yuyan Weng, Yujiang Dou, Bing Yuan, Kai Yang,and Yuqiang Ma. Reduced graphene oxide directed self-assembly of phospholipid monolayers in liquid and gel phases. BBA-Biomembranes, 2015, 1848, 1203-1211.

20. HaoYang, Ling Wang, Bing Yuan, Kai Yang*, and Yuqiang Ma. Adhesion of an Ultrasmall Nanoparticle on a Bilayer Membrane is Still Size and Shape Dependent. Journal of Materials Science & Technology, 2015, 31, 660-663 (Invited Paper).

19. Xiao Li, Meimei Bao, Yuyan Weng, Kai Yang, Weidong Zhang and Gaojian Chen. Glycopolymer-coated iron oxide nanoparticles: shape-controlled synthesis and cellular uptake. J. Mater. Chem. B, 2014, 2, 5569-5575.

18. Haizhen Zhang, Ling Wang, Bing Yuan, Kai Yang*, and Yuqiang Ma. Effect of Receptor Structure and Length on the Wrapping of a Nanoparticle by a Lipid Membrane. Materials, 2014, 7, 3855-3866.

17. Jiaojiao Liu, Jingliang Li, Zexin Zhang, Yuyan Weng, Gaojian Chen, Bing Yuan*, Kai Yang, and Yuqiang Ma*. Encapsulation of Hydrophobic Phthalocyanine with Poly(N-isopropylacrylamide)/Lipid Composite Microspheres for Thermo-ResponsiveRelease and Photodynamic Therapy. Materials, 2014, 7, 3481-3493.

16. Naiyan Lu, Jiaojiao Liu, Jingliang Li, Zexin Zhang, Yu-yan Weng, Bing Yuan*, Kai Yang, and Yu-qiang Ma*. Tunable Dual-stimuli Response of a Microgel Composite Consisting of Reduced Graphene Oxide Nanoparticles and Poly(Nisopropylacrylamide) Hydrogel Microsphere. J. Mater. Chem. B, 2014, 2,3791-3798.

15. Yujiang Dou, Jingliang Li, Bing Yuan*, Kai Yang*. Lipid merging, protrusion and vesiclerelease triggered by shrinking/swelling of poly(N-isopropylacrylamide) microgelparticles. Appl. Surf. Sci., 2014, 296(30), 95-99.

14. Naiyan Lu, Bing Yuan*, Kai Yang*. Nonspecific adsorption of charged mesoporous nanoparticles on supported thiol/lipid hybrid bilayers. Acta Phys. Sin., 2013,62 (17), 178701.

13. Naiyan Lu, Kai Yang, Jingliang Li, Yuyan Weng, Bing Yuan, and Yuqiang Ma, Controlled Drug Loading and Release of a Stimuli-responsive Lipogel Consisting of Poly(N-isopropylacrylamide) Particle and Lipids, J. Phys. Chem. B, 2013,117(33), 9677–9682.

12. Jiaojiao Liu, Naiyan Lu, Jingliang Li, Yuyan Weng, Bing Yuan*, Kai Yang*, and Yuqiang Ma. Influence of Surface Chemistry on Particle Internalization into Giant Unilamellar Vesicles. Langmuir, 2013, 29 (25), 8039–8045.

11. Kai Yang, Bing Yuan, Yuqiang Ma. Influence of geometric nanoparticle rotation oncellular internalization Process. Nanoscale, 2013, 5, 7998–8006.

10. Naiyan Lu, Kai Yang, Jingliang Li, Bing Yuan, and Yuqiang Ma, Vesicle Deposition and Subsequent Membrane-melittin Interactions on Different Substrates: a QCM-DExperiment, BBA-Biomembranes, 2013, 1828, 1918-1925.

9. Naiyan Lu, Kai Yang, Bing Yuan and Yuqiang Ma, Molecular Response and Cooperative Behavior during the Interactions of Melittin with a Membrane: Dissipative Quartz Crystal Microbalance Experiments and Simulations, J. Phys. Chem. B, 2012, 116, 9432-9438.

8. Kai Yang, Bing Yuan, Yuqiang Ma. Curvature Changes of Bilayer Membranes Studied by Computer Simulations. J. Phys. Chem. B, 2012, 116, 7196-7202.

7. Ye Li, Tongtao Yue, Kai Yang*, Xianren Zhang. Molecular modeling of therelationship between nanoparticle shape anisotrcopy and endocytosis kinetics. Biomaterials, 2012, 33, 4965-4973.

6. Kai Yang, Yuqiang Ma. Computer simulations of fusion, fission and shape deformationin lipid membranes. Soft Matter, 2012, 8, 606-618 (Invited Review).

5. Kai Yang, Yuqiang Ma. Wrapping and Internalization of Nanoparticles by Lipid Bilayers: a Computer Simulation Study. Aust. J. Chem., 2011, 64, 894–899.

4. Xi Shao, Kai Yang, Yuqiang Ma. A dissipative particle dynamics study on the morphologies of H-shaped block copolymers in solvent. Int. J. Mod. Phys. B, 2011, 25(6), 843–850.

3. Kai Yang, Yuqiang Ma. Computer Simulation of the Translocation of Nanoparticleswith Different Shapes Across a Lipid Bilayer. Nature Nanotechnology, 2010, 5, 579-583 (Highlighted by Nature China).

2. Kai Yang, Yuqiang Ma. Computer Simulations of Vesicle Fission Induced by External Amphipathic Inclusions. J. Phys. Chem. B, 2009, 113,  1048-1057.

1. Kai Yang, Xi Shao, Yuqiang Ma. Shape deformation and fission route of the lipid domain in a multicomponent vesicle. Phys. Rev. E, 2009, 79,  051924 (Highlightedby PRE Kaleidoscope).


荣誉及奖励

荣誉及奖励:

Teaching

开授课程:课程教学:

研究生课程:

1. 软物质物理
2. 现代物理化学材料研究进展讲座
3. 应用英语(高水平论文与专利的构思与写作)


本科生课程:

1. 普通物理二
2. 普通物理三
3. 医用物理
4. 科学讲座


招生信息

招生信息: 招生信息1:

课题组招收博/硕士研究生!

本课题组同时开展分子模拟和与实验研究,注重模拟与实验的结合,研究领域具有多学科交叉的特点,招生方向包括:物理学,化学,材料学等,欢迎具有物理,化学、生物、材料、数学或计算机等背景的同学报考。

课题组欢迎对科学研究感兴趣的本科生到实验室学习

欢迎本科生同学到实验室开展“大学生创新计划”等活动。欢迎暑期交流学生。
课题组与国外多所知名大学课题组有良好的合作关系,可进行学生联合培养和交流。


课题组欢迎相关背景的博士后(表现突出者可留校,并可申请苏大优秀青年学者,年薪20-30万元)!